VideosThe following video(s) are recommended for use in association with this case study.
Short Film: The Making of the Fittest: Natural Selection in Humans
A keenly observant young man named Tony Allison, working in East Africa in the 1950s, first noticed the connection and assembled the pieces of the puzzle. His story stands as the first and one of the best understood examples of natural selection, where the selective agent, adaptive mutation, and molecule involved are known - and this is in humans to boot. The protection against malaria by the sickle-cell mutation shows how evolution does not necessarily result in the best solution imaginable but proceeds by whatever means are available. Produced by HHMI BioInteractive. Running time: 14:03 min.
Film Guide: The Making of the Fittest: Natural Selection in Humans
This guide and quiz support the short film "The Making of the Fittest: Natural Selection in Humans." The "At a Glance Film Guide" provides a short summary of the film, along with key concepts and ties to selected curricula and textbooks. The "In-Depth Film Guide for Teachers" includes a more detailed summary and background information, discussion points, lists of related resources and references, and answers to the accompanying student quiz. The "Quiz" is designed as a summative assessment that probes student understanding of the key concepts addressed in the film. Produced by HHMI BioInteractive.
Animation: Sickle Cell Anemia
A one-minute animation about sickle cell anemia, a genetic disease that affects hemoglobin. A single nucleotide change in the hemoglobin gene causes an amino acid substitution in the hemoglobin protein from glutamic acid to valine. The resulting proteins stick together to form long fibers and distort the shape of the red blood cells. Produced by HHMI BioInteractive. Running time: 1:00 min.
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